The Molecular Virulence of Legionnaires' Disease Bacterium.

Legionella pneumophila, a facultative intracellular pathogen is responsible for about 85% of cases of the legionelloses Legionnaires disease and Pontiac fever (Dowling et al., 1992; Fields, 1997). These ar a outgrowth of the accompaniment that man has created additional environmental reservoirs for these opportunistic pathogens, providing them with a heart by which they can be disseminated in aerosols and uncovered to mankind (Fields, 1997; Shuman et al., 1998). While both forms of legionellosis be caused by inhalation of commensurate numbers of aerosolised legionellae by a pliable soldiers (Fields 1997), Pontiac fever which is the non pneumonic and less severe kind of sickness is not provoked by tissue invasion so it may be caused by strains of Legionella incapable of intracellular multiplication (Dowling et al., 1992). Furthermore, it may involve a contact-dependent cytotoxic toss up on the host cell surface (Husmann and Johnson, 1994). These bacteria atomic number 18 characterised as gram negative, oxidative rods (Fields, 1997) and possess a champion flagellum with a 47kDa string subunit, the presence of which predicts virulence (Bosshardt et al., 1997). In the environment, legionellae are endosymbionts of freshwater phylum Protozoa (Byrne and Swanson, 1998), thus they obtain their nutrients from, and multiply in an intracellular environment. At the same time they are ubiquitous in freshwater environments, present at low concentrations in these aquatic reservoirs (Fields, 1997). therefrom the bacteria must have or so way to be able to adapt for its selection in diametrical conditions (Byrne and Swanson, 1998).

For example, Legionella are s usceptible to UV light, and plasmids mediati! ng opposite to UV radiation may be crucial in the pathogens survival in both natural and manmade water systems (Tully, 1993). Byrne has suggested that when nutrients are verdant in an intracellular environment, L. pneumophila are dedicated to reverberation and do not express factors correlated with virulence. When nutrients become... Having a medical background, this is in truth nice, my be a little overwhelming for the layman person. in truth nice work. Would be nice to have the preference summon with this essay, too; please. If you want to get a sound essay, tack it on our website: OrderEssay.net

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